Type II casein kinase (CK-2) is unique among the protein kinases since it can use ATP as well as GTP as a phosphoryl donor. It is extremely sensitive to heparin inhibition and can be activated by polyamines and basic polypeptides. 

II型酪蛋白激酶（CK-2）在蛋白激酶中是独特的，因为它可以使用ATP和GTP作为磷酸供体。它对肝素抑制极为敏感，可被多胺和碱性多肽激活。

Casein kinase 2 (CK2) is a highly conserved and ubiquitous eukaryotic Ser/Thr protein kinase. Genetic, biochemical, and cell biological studies have indicated the involvement of this enzyme in the control of cell proliferation and in signal transduction. the peptide RRRDDDSDDD turned out to be an even better substrate than the peptide RRREEESEEE.

酪蛋白激酶2（CK2）是一种高度保守且普遍存在的真核细胞Ser/Thr蛋白激酶。遗传学、生物化学和细胞生物学研究表明，这种酶参与控制细胞增殖和信号转导。

Casein kinase II peptide (RRRDDDSDDD) dose-dependently (IC50 = 50 μM) inhibited β-hexosaminidase release by IgE-sensitized antigen-stimulated RBL-2H3 cells, whereas casein kinase II peptide analogue (RRRDDDADDD) only partially inhibited β-hexosaminidase release by antigen-stimulated RBL-2H3 cells. 

酪蛋白激酶II肽（RRRDDDSDDD）剂量依赖性地（IC50=50μM）抑制IgE致敏的抗原刺激的RBL-2H3细胞释放β-己糖胺酶，而酪蛋白激酶II类似物（RRRDDD）仅部分抑制抗原刺激的RBS-2H3细胞的β-己糖胺酶。

1, Miwako Kato Homma & Yoshimi Homma1. Cell cycle and activation of CK2. Molecular and Cellular Biochemistry. Volume 316, pages 49–55, (2008)

2, Jun-ichi Onose, Reiko Teshima, Rhosuke Nakamura, Jun-ichi Sawada. Inhibition of Degranulation of RBL-2H3 Cells by Casein Kinase II Substrate Peptide

3, Kissmehl R, Treptau T , Hauser K , Plattner H. A novel, calcium-inhibitable casein kinase in Paramecium cells. FEBS Letters, 01 Feb 1997, 402(2-3):227-235